My research work in recent years has focused on discovering the role that N-degron pathways (formally known as the N-end rule pathway of ubiquitin-mediated proteolysis) play in regulating plant growth and development and response to the environment. This has included our discoveries that the Cys branch of the PRT6 N-degron pathway acts as the molecular mechanism for oxygen sensing in flowering plants (Nature 2011), that it acts as a key nitric oxide sensing mechanism in plants (Molecular Cell, 2014), controls response to multiple abiotic stresses (Current Biology 2017) biotic stresses (New Phytologist 2018), photomorphogenesis (Current Biology 2015), influences the stability of key regulatory proteins (Nature Communications 2018), and that manipulation of the pathway leads to water-logging tolerant barley (Plant Biotechnology Journal 2016).

Career Status:
Faculty/Group Leader, Major Research University: Post-Tenure

Research Areas:
Abiotic Interactions, Botany, Gene Regulation, Genetics


  • MILLAR AH, HEAZLEWOOD JL, GIGLIONE C, HOLDSWORTH MJ, BACHMAIR A and SCHULZE WX, 2019. The Scope, Functions, and Dynamics of Posttranslational Protein Modifications. Annual review of plant biology. Vol. 70: 119–51. DOI:10.1146/annurev-arplant-050718-100211
  • GIBBS, D. J., TEDDS, H. M., LABANDERA, A-M., BAILEY, M., WHITE, M. D., HARTMAN, S., SPRIGG, C., MOGG, S. L., OSBORNE, R., DAMBIRE, C., BOECKX, T., PALING, Z., VOESENEK, L. A. C. J., FLASHMAN, E. and HOLDSWORTH, M. J., 2018. Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2 NATURE COMMUNICATIONS. 9, 
  • VICENTE J, MENDIONDO GM, MOVAHEDI M, PEIRATS-LLOBET M, JUAN YT, SHEN YY, DAMBIRE C, SMART K, RODRIGUEZ PL, CHARNG YY, GRAY JE and HOLDSWORTH MJ, 2017. The Cys-Arg/N-End Rule Pathway Is a General Sensor of Abiotic Stress in Flowering Plants. Current Biology. 27, 3183-3190
  • GIBBS, D.J., LEE, S.C., ISA, N.M., GRAMUGLIA, .S, FUKAO, T., BASSEL, G.W., CORREIA, C.S., CORBINEAU, F., THEODOULOU, F.L., BAILEY-SERRES, J. and HOLDSWORTH, M.J., 2011. Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants. Nature. 479(7373), 415-418
  • Interests
    Current Affiliations
    Experience & Education