Bio

Liz Haswell earned her PhD in Biochemistry at the University of California, San Francisco with Erin O’Shea, working on chromatin remodeling in yeast. She then switched to plant systems for her postdoctoral work at Caltech with Elliot Meyerowitz. There she fell in love with plants and with mechanobiology and began studying mechanosensitive ion channels in plants. She joined the faculty in the Biology department at WUSTL in 2007. Her group’s work has been published in Science, PNAS, Development, and Current Biology, and is funded by NSF, NIH, NASA, and the Gordon and Betty Moore Foundation. She is a member of the inaugural class of HHMI Faculty-Scholars. She is co-chair of the multi-national Arabidopsis Steering Committee and on the Steering Committee for the NSF Center for Engineering Mechanobiology based at WUSTL and at University of Pennsylvania. She is married, has a 7-year-old daughter, and spent last spring on sabbatical on the South Island of New Zealand

Research Areas:
Cell Biology, Development, Genetics, Molecular Biology, Physiology

Publications

1.     E. S. Hamilton2 & E. S. Haswell. (2017). The Tension-sensitive Ion Transport Activity of MSL8 is Critical for its Function in Pollen Hydration and Germination. Plant Cell and Physiology, in press. Preprint highlighted on The Node blog.

2.     G. Jensen, K. Fal, O. Hamant and E. S. Haswell. The RNA Polymerase-Associated Factor 1 (Paf1) Complex is Required for Touch Responses in Plants. (2017). Journal of Experimental Botany 68:499-511.

3.     C. P. Lee, G. Maksaev, G. Jensen, M. Murcha, M. E. Wilson, M. Fricker, R. Hell, E. S. Haswell, A. H. Millar and L. Sweetlove. (2016). MSL1 is a mitochondrial mechanosensitive ion channel that dissipates membrane potential and maintains redox homeostasis in mitochondria during abiotic stress. Plant Journal 88:809-825.

4.     M. E. Wilson, Matt Mixdorf, R. H. Berg and E. S. Haswell. (2016). Plastid Osmotic Shock Influences Dedifferentiation at the Plant Shoot Apex. Development 143: 3382-3393.

5.     D. R. Luesse, M. E. Wilson and E. S. Haswell. (2015). RNA-Sequencing Analysis of the msl2msl3, crl, and ggps1 Mutants Indicates that Diverse Sources of Plastid Dysfunction do not Alter Leaf Morphology Through a Common Signaling Pathway. Frontiers in Plant Science 6:1148.

6.     E. S. Hamilton2, G. S. Jensen, G. Maksaev, A. Katims1, A.M. Sherp2 and E. S. Haswell. (2015). Mechanosensitive Ion Channel MSL8 Regulates Osmotic Forces During Pollen Hydration and Germination. Science 350:438-441.

7.     S. M. Brady, M. Burow, W. Busch, O. Carlborg, K. J. Denby, J. Glazebrook, E. S. Hamilton2, S. Harmer, E. S. Haswell, J. N. Maloof, D. Kliebenstein. (2015). Reassess the t-test: Interact With All Your Data Via ANOVA. Plant Cell 27:2088-94.

8.     E. S. Haswell and P. E. Verslues. (2015). The Ongoing Search for the Molecular Basis of Plant Mechanosensing. Journal of General Physiology 145:398-394. Featured on the cover of the May 2015 issue.

9.     E. S. Hamilton2, A. Schlegel2, and E. S. Haswell. (2015). United in Diversity: Plant Mechanosensitive Channels. Annual Review of Plant Biology 66:113-137.

10.  K. M. Veley, G. Maksaev, S. M. Kloepper1, E. M. Frick2, E. January and E. S. Haswell. (2014). MSL10 has a Regulated Cell Death Signaling Activity that is Separable from its Mechanosensitive Ion Channel Activity. Plant Cell 26:3115-31.

11. S. Bell, J. Blumstein, K. Brose, A. Carroll, J. Chang, J. Charles, E. S. Haswell, M. Michelitsch, J. Owens, C. K. Patil, R. Smith, J. Tupy, E. Walsh, T. Ware. (2014). Defining Success in Graduate School. Molecular Biology of the Cell 25:1942-1944.

12.  M. E. Wilson2, M. R. Basu1, G. B. Bhaskara, P. E. Verslues, and E. S. Haswell. (2014). Plastid Osmotic Stress Activates Cellular Osmotic Stress Responses. Plant Physiology 165:119-128.  

13.  M.E. Wilson2, G. Maksaev, and E. S. Haswell. (2013). MscS-like Mechanosensitive Ion Channels in Plants and Microbes. Biochemistry 52 (34): 5708–5722.

14.  G. E. Monschausen & E. S. Haswell. (2013). A Force of Nature: Molecular Mechanisms of Mechanoperception. J. Experimental Botany 64(15):4663-80.

15.  G. Maksaev and E. S. Haswell. (2013). Recent Characterizations of MscS and its Homologs Provide Insights into the Basis of Ion Selectivity. Channels 7(3):215-220. Featured on the cover of the May/June 2013 issue.

16.  G. Maksaev and E. S. Haswell. (2012). MscS-Like10 is a Stretch-Activated Ion Channel from Arabidopsis thaliana with a Preference for Anions. Proceedings of the National Academy of Sciences 109:19015-19020.

17.  G. S. Jensen and E. S. Haswell. (2012). Functional Analysis of Conserved Motifs in the Mechanosensitive Channel Homolog MscS-Like2 from Arabidopsis thaliana, PLOS ONE 7(6):e40336.

18.  K. M. Veley, S. Marshburn, C. Clure1 and E. S. Haswell. (2012). Mechanosensitive Channels Protect Plastids from Hypoosmotic Shock During Normal Plant Growth. Current Biology 22:408-413.

19.  K. M. Veley and E. S. Haswell.  (2012). Plastids and Pathogens: Mechanosensitive Channels and Survival in a Hypoosmotic World. Plant Signaling & Behavior 7:668-671.

20.  M. E. Wilson2 and E. S. Haswell.  (2012). A Role for Mechanosensitive Channels in Chloroplast and Bacterial Fission.  Plant Signaling & Behavior 7:157-60.

21.  G. Maksaev and E. S. Haswell. (2011). Expression and Characterization of the Bacterial Mechanosensitive Channel MscS in Xenopus laevis Oocytes.  J. General Physiology 138: 641-9.

22.  M. E. Wilson2, G. S. Jensen, and E. S. Haswell. (2011). Two Mechanosensitive Channel Homologs Influence FtsZ Ring Placement in Arabidopsis. Plant Cell 23: 2939-2949. Featured on the cover of the May/June 2013 issue.

23.  E. S. Haswell, R. Phillips, and D. R. Rees. (2011).  Mechanosensitive Channels:  What Do They Do and How Do They Do It? Structure 19: 1356-1369.

24.  E. S. Haswell3, R. Peyronnet3, H. Barbier-Brygoo, E. M. Meyerowitz, and J-M. Frachisse. (2008). Two MscS Homologues Required for Mechanosensitive Channel Activities in the Arabidopsis Root. Current Biology 18: 730-734.                              

25.  R. Peyronnet, E. S. Haswell, H. Barbier-Brygoo, and J-M. Frachisse. (2008). AtMSL9 and AtMSL10:  Sensors of Plasma Membrane Tension in the Arabidopsis Root.  Plant Signaling & Behavior 3: 726-729.

26.  E. S. Haswell and E. M. Meyerowitz. (2006). MscS-like Proteins Control Plastid Size and Shape in Arabidopsis thaliana. Current Biology 16: 1-11. Dispatch: K. Pyke. (2006). Plastid Division: the Squeezing gets Tense. Current Biology 16: R60-2                 

27.  E. S. Haswell. (2003). Gravity Perception: How Plants Stand up for Themselves. Current Biology 13: R761-R763

28.  D. J. Steger, E. S. Haswell, A. L. Miller, S. R. Wente, and E. K. O’Shea. (2003). Regulation of Chromatin Remodeling by Inositol Polyphosphates. Science 5603: 114-116.

29.  E. S. Haswell and E. K. O'Shea. (1999). An In Vitro System Recapitulates Chromatin Remodeling at the PHO5 Promoter. Molecular and Cellular Biology 19: 2817-2827.

30.  E. S. Haswell and E. K. O'Shea. (1998). Specificity of ATP-Dependent Chromatin Remodeling at the Yeast PHO5 Promoter. Cold Spring Harbor Symposium on Quantitative Biology 63: 563-567.

Interests
Current Affiliations
Experience & Education